Matt Damon has admitted the biggest regret of his career was turning down Avatar movie in 2009, in which he would have earned approx $250 million and appeared alongside Zoe Saldana.

The 52-year-old actor, who has teamed up with Saldana for Stella Artois' new Let's Do Dinner campaign, was offered the lead role in James Cameron's movie, which was later played by Sam Worthington, while Saldana portrayed Neytiri.

In an exclusive conversation with ET, the Oppenheimer star confessed, "it’s the dumbest thing an actor ever did in the history of acting."

Saldana, who was also present with Damon chimed in, "I don’t think your career suffered because of it, trust me."

To which the actor quickly responded saying, "do you know what kind of movie that would’ve been if I would had been in it?"

Then she jokingly replied, "I didn't plan it, trust me. I've just always felt blessed that I was picked, that I worked really hard and auditioned. I'm not Matt Damon. I don't get to turn down Avatars."

"I've probably done, like, 50 movies. I've never been in a movie that made $1 billion," noted the Good Will Hunting actor. 

Damon will also be seen in Christopher Nolan's Oppenheimer, releasing in theatres on July 21, 2023.